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Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications.

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第一作者： Daniel,Desaulniers

第一单位： Environmental Health Sciences and Research Bureau, Hazard Identification Division, Health Canada, AL:2203B, Ottawa, ON K1A 0K9, Canada.

作者： Daniel,Desaulniers ^[1] ; Paule,Vasseur ^[2] ; Abigail,Jacobs ^[3] ; M Cecilia,Aguila ^[4] ; Norman,Ertych ^[5] ; Miriam N,Jacobs ^[6]

作者单位： Environmental Health Sciences and Research Bureau, Hazard Identification Division, Health Canada, AL:2203B, Ottawa, ON K1A 0K9, Canada. ^[1] CNRS, LIEC, Université de Lorraine, 57070 Metz, France. ^[2] Independent at the Time of Publication, Previously US Food and Drug Administration, Rockville, MD 20852, USA. ^[3] Toxicology Team, Division of Human Food Safety, Center for Veterinary Medicine, US Food and Drug Administration, Department of Health and Human Services, Rockville, MD 20852, USA. ^[4] German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment, Diedersdorfer Weg 1, 12277 Berlin, Germany. ^[5] Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton OX11 0RQ, UK. ^[6]

关键词 AOP DNA methylation IATA carcinogens epigenetics histone modifications mode of action non-genotoxic risk assessment