首页> International journal of molecular sciences> Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA.

Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA.

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第一作者： Lisa Marie,Krieger

第一单位： Department of Radiation Therapy, Division of Experimental Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.;Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.

作者： Lisa Marie,Krieger ^[1] ; Emil,Mladenov ^[1] ; Aashish,Soni ^[1] ; Marilen,Demond ^[2] ; Martin,Stuschke ^[3] ; George,Iliakis ^[1]

作者单位： Department of Radiation Therapy, Division of Experimental Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.;Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany. ^[1] Institute of Medical Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany. ^[2] Department of Radiation Therapy, Division of Experimental Radiation Biology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.;German Cancer Consortium (DKTK), Partner Site University Hospital Essen, German Cancer Research Center (DKFZ), 45147 Essen, Germany. ^[3]

关键词 DNA double-strand breaks DNA-damage-response alternative end-joining (alt-EJ)chromatin chromatin dynamics homologous recombination (HR)hypotonic stress (HypoS)ionizing radiation (IR)nonhomologous end-joining (NHEJ)single-strand annealing (SSA)