Drug Penetration into the Central Nervous System: Pharmacokinetic Concepts and In Vitro Model Systems.

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作者： Felix,Neumaier ^[1] ; Boris D,Zlatopolskiy ^[2] ; Bernd,Neumaier ^[1]

作者单位： Institute of Radiochemistry and Experimental Molecular Imaging, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany. ^[1] Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, Nuclear Chemistry (INM-5), Wilhelm-Johnen-Str., 52428 Jülich, Germany. ^[2]

关键词 BBB permeability co-culture model dynamic BBB model immobilized artificial membrane (IAM) chromatography microfluidic BBB model monolayer neurotracer parallel artificial membrane permeability assay (PAMPA)positron emission tomography (PET)static BBB model

DOI 10.3390/pharmaceutics13101542

PMID 34683835

发布时间 2023-11-07

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