Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (<i>Mycobacterium tuberculosis</i>) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs.

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作者： Sourya,Bhattacharya ^[1] ; Vivek,Junghare ^[1] ; Niteesh Kumar,Pandey ^[1] ; Subhecchha,Baidya ^[1] ; Harsha,Agarwal ^[1] ; Neeladrisingha,Das ^[1] ; Ayan,Banerjee ^[2] ; Debashish,Ghosh ^[3] ; Partha,Roy ^[2] ; Hirak K,Patra ^[3] ; Saugata,Hazra ^[1]

作者单位： Department of Biosciences and Bioengineering, Indian Institute of Technology Roorkee, Roorkee, India. ^[1] Biochemistry and BIotechnology Area, Material Resource Efficiency Division, CSIR-Indian Institute of Petroleum, Dehradun, India. ^[2] Academy of Scientific and Innovative Research, Ghaziabad, India. ^[3] Department of Surgical Biotechnology, University College London, London, United Kingdom. ^[4] Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, India. ^[5]

关键词 MD simulation Mycobacterium tuberculosis antimicrobial resistance (AMR)combinatorial therapeutics conserved loop extensively drug-resistant (XDR)mechanism-based inhibitors (MBI)multidrug-resistant (MDR)

DOI 10.3389/fmicb.2021.710291

PMID 34690953

发布时间 2021-10-26

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Frontiers in microbiology

2021年12卷

710291页

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Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (<i>Mycobacterium tuberculosis</i>) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs.

Frontiers in microbiology

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Frontiers in microbiology

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Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (<i>Mycobacterium tuberculosis</i>) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs.

Frontiers in microbiology

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Frontiers in microbiology

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