Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project.

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第一作者： Nina,Wilson

第一单位： Population Health Sciences Institute, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, UK.

作者： Nina,Wilson ^[1] ; Katie,Biggs ^[2] ; Sarah,Bowden ^[3] ; Julia,Brown ^[4] ; Munyaradzi,Dimairo ^[2] ; Laura,Flight ^[2] ; Jamie,Hall ^[2] ; Anna,Hockaday ^[4] ; Thomas,Jaki ^[5] ; Rachel,Lowe ^[6] ; Caroline,Murphy ^[7] ; Philip,Pallmann ^[8] ; Mark A,Pilling ^[7] ; Claire,Snowdon ^[9] ; Matthew R,Sydes ^[10] ; Sofía S,Villar ^[11] ; Christopher J,Weir ^[5] ; Jessica,Welburn ^[12] ; Christina,Yap ^[2] ; Rebecca,Maier ^[10] ; Helen,Hancock ^[1] ; James M S,Wason ^[13]

作者单位： Population Health Sciences Institute, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, UK. ^[1] School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK. ^[2] Cancer Research UK Clinical Trials Unit (CRCTU), University of Birmingham, Birmingham, UK. ^[3] Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK. ^[4] MRC Biostatistics Unit, University of Cambridge, Cambridge, UK. ^[5] Department of Mathematics and Statistics, Lancaster University, Lancaster, UK. ^[6] Centre for Trials Research, Cardiff University, Cardiff, UK. ^[7] King's College Trials Unit, King's College London, London, UK. ^[8] Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. ^[9] The Institute of Cancer Research Clinical Trials & Statistics Unit, London, UK. ^[10] MRC Clinical Trials Unit at UCL, London, UK. ^[11] Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK. ^[12] Newcastle Clinical Trials Unit, Newcastle University, Newcastle upon Tyne, UK. ^[13] Population Health Sciences Institute, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne, NE2 4AX, UK. james.wason@newcastle.ac.uk. ^[14]

关键词 Adaptive clinical trials Adaptive designs Clinical trials Efficiency Resource requirements Trial coordination

主题词费用效益分析(Cost-Benefit Analysis);人类(Humans);研究设计(Research Design);研究人员(Research Personnel)

DOI 10.1186/s12916-021-02124-z

PMID 34696781

发布时间 2024-02-10

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