Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils.-论文-万方医学网

作者： Yusuke,Kimishima ^[1] ; Tomofumi,Misaka ^[2] ; Tetsuro,Yokokawa ^[3] ; Kento,Wada ^[1] ; Koki,Ueda ^[4] ; Koichi,Sugimoto ^[1] ; Keiji,Minakawa ^[5] ; Kazuhiko,Nakazato ^[1] ; Takafumi,Ishida ^[4] ; Motohiko,Oshima ^[5] ; Shuhei,Koide ^[1] ; Kotaro,Shide ^[1] ; Kazuya,Shimoda ^[6] ; Atsushi,Iwama ^[6] ; Kazuhiko,Ikeda ^[7] ; Yasuchika,Takeishi ^[7]

作者单位： Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan. ^[1] Department of Cardiovascular Medicine, Fukushima Medical University, Fukushima, Japan. misaka83@fmu.ac.jp. ^[2] Department of Advanced Cardiac Therapeutics, Fukushima Medical University, Fukushima, Japan. misaka83@fmu.ac.jp. ^[3] Department of Pulmonary Hypertension, Fukushima Medical University, Fukushima, Japan. ^[4] Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan. ^[5] Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ^[6] Department of Gastroenterology and Hematology, University of Miyazaki, Miyazaki, Japan. ^[7] Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, Fukushima, Japan. kazu-ike@fmu.ac.jp. ^[8]

主题词激活素受体,Ⅱ型(Activin Receptors, Type II);动物(Animals);骨髓细胞(Bone Marrow Cells);细胞系, 肿瘤(Cell Line, Tumor);人类(Humans);高血压, 肺性(Hypertension, Pulmonary);Janus激酶2(Janus Kinase 2);肺(Lung);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);突变(Mutation);骨髓增殖性疾病(Myeloproliferative Disorders);中性白细胞浸润(Neutrophil Infiltration);中性白细胞(Neutrophils);磷酰化(Phosphorylation);患病率(Prevalence);STAT3转录因子(STAT3 Transcription Factor);信号传导(Signal Transduction);Smad蛋白质类(Smad Proteins);增量调节(Up-Regulation)

DOI 10.1038/s41467-021-26435-0

PMID 34702814

发布时间 2023-02-07

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Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils.

Nature communications

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Nature communications

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Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils.

Nature communications

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Nature communications

相关期刊

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