Replacing Saturated Fat with Polyunsaturated Fat Modulates Peripheral Blood Mononuclear Cell Gene Expression and Pathways Related to Cardiovascular Disease Risk Using a Whole Transcriptome Approach.

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作者： Sunniva V,Larsen ^[1] ; Kirsten B,Holven ^[1] ; Jacob J,Christensen ^[2] ; Arnar,Flatberg ^[1] ; Amanda,Rundblad ^[2] ; Lena,Leder ^[3] ; Rune,Blomhoff ^[4] ; Vibeke,Telle-Hansen ^[1] ; Marjukka,Kolehmainen ^[5] ; Carsten,Carlberg ^[1] ; Mari C,Myhrstad ^[6] ; Magne,Thoresen ^[7] ; Stine M,Ulven ^[8]

作者单位： Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Blindern, Oslo, Norway. ^[1] Department of Endocrinology, Morbid Obesity and Preventive Medicine, Norwegian National Advisory Unit on Familial Hypercholesterolemia, Oslo University Hospital, Nydalen, Oslo, Norway. ^[2] Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. ^[3] Central Administration, St. Olavs Hospital, The University Hospital in Trondheim, Trondheim, Norway. ^[4] Mills AS, Oslo, Norway. ^[5] Department of Clinical Service, Division of Cancer Medicine, Oslo University Hospital, Oslo, Norway. ^[6] Department of Nutrition, Faculty of Health Sciences, Oslo Metropolitan University, St. Olavs Plass, Oslo, Norway. ^[7] Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. ^[8] School of Medicine, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. ^[9] Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Blindern, Oslo, Norway. ^[10]

关键词 LDL cholesterol cardiovascular disease risk dietary fat quality gene expression inflammation

主题词心血管疾病(Cardiovascular Diseases);膳食脂肪类(Dietary Fats);脂肪酸类(Fatty Acids);人类(Humans);白细胞, 单核(Leukocytes, Mononuclear)

DOI 10.1002/mnfr.202100633

PMID 34708513

发布时间 2022-04-01

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