换一批
换一批Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA<sub>1</sub>) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.
第一作者：
Peter T W,Cheng
第一单位：
Fibrosis Chemistry, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
作者：
Peter T W,Cheng [1]
;
Robert F,Kaltenbach [1]
;
Hao,Zhang [1]
;
Jun,Shi [1]
;
Shiwei,Tao [1]
;
Jun,Li [1]
;
Lawrence J,Kennedy [1]
;
Steven J,Walker [1]
;
Yan,Shi [1]
;
Ying,Wang [1]
;
Suresh,Dhanusu [2]
;
Ramesh,Reddigunta [2]
;
Selvakumar,Kumaravel [2]
;
Sutjano,Jusuf [3]
;
Daniel,Smith [4]
;
Subramaniam,Krishnananthan [4]
;
Jianqing,Li [5]
;
Tao,Wang [6]
;
Rebekah,Heiry [6]
;
Chi Shing,Sum [6]
;
Stephen S,Kalinowski [7]
;
Chen-Pin,Hung [7]
;
Ching-Hsuen,Chu [7]
;
Anthony V,Azzara [7]
;
Milinda,Ziegler [7]
;
Lisa,Burns [7]
;
Bradley A,Zinker [7]
;
Stephanie,Boehm [7]
;
Joseph,Taylor [7]
;
Julia,Sapuppo [7]
;
Kathy,Mosure [8]
;
Gerry,Everlof [9]
;
Victor,Guarino [10]
;
Lisa,Zhang [10]
;
Yanou,Yang [11]
;
Qian,Ruan [11]
;
Carrie,Xu [12]
;
Atsu,Apedo [13]
;
Sarah C,Traeger [14]
;
Mary Ellen,Cvijic [6]
;
Kimberley A,Lentz [10]
;
Giridhar,Tirucherai [15]
;
Lakshmi,Sivaraman [16]
;
Jeffrey,Robl [1]
;
Bruce A,Ellsworth [1]
;
Glenn,Rosen [7]
;
David A,Gordon [7]
;
Matthew G,Soars [8]
;
Michael,Gill [17]
;
Brian J,Murphy [7]
作者单位：
Fibrosis Chemistry, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[1]
Biocon-Bristol Myers Squibb Research & Development Center, Bangalore 560099, India.
[2]
Computer Aided Drug Design, Molecular Structure & Design, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[3]
Discovery Chemistry Synthesis, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[4]
Discovery Chemistry Synthesis, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Cambridge, Massachusetts 02140, United States.
[5]
Lead Evaluation, Small Molecule Drug Discovery, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[6]
Cardiovascular & Fibrosis Discovery Biology, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[7]
Metabolism & Pharmacokinetics, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Cambridge, Massachusetts 02140, United States.
[8]
Pharmaceutics, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[9]
Metabolism & Pharmacokinetics, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[10]
Biotransformation, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[11]
Bioanalytical Chemistry, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[12]
Discovery Analytical Sciences, Preclinical Candidate Optimization, Research & Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[13]
Discovery Analytical Sciences, Small Molecule Drug Discovery, Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[14]
Clinical Pharmacology, Immunology, Cardiovascular and Fibrosis, Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-5326, United States.
[15]
Nonclinical Safety Evaluation, Research & Development, Bristol Myers Squibb Company, New Brunswick, New Jersey 08903-0191, United States.
[16]
Discovery Toxicology, Preclinical Candidate Optimization, Research and Early Development, Bristol Myers Squibb Company, Princeton, New Jersey 08543-4000, United States.
[17]
主题词
动物(Animals);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物发现(Drug Discovery);男(雄)性(Male);小鼠(Mice);分子结构(Molecular Structure);肺纤维化(Pulmonary Fibrosis);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 溶血磷脂酸(Receptors, Lysophosphatidic Acid);构效关系(Structure-Activity Relationship)
DOI
10.1021/acs.jmedchem.1c01256
PMID
34709814
发布时间
2021-12-14
- 浏览2
Journal of medicinal chemistry
Journal of medicinal chemistry
15549-15581页
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