The SGLT2-inhibitor dapagliflozin improves neutropenia and neutrophil dysfunction in a mouse model of the inherited metabolic disorder GSDIb.
作者:
关键词
1,5-anhydroglucitol-6-phosphate1,5AG, 1,5-anhydroglucitol1,5AG6P, 1,5-anhydroglucitol-6-phosphateBM, bone marrowCFU, colony forming unitsDapagliflozinG-CSF, granulocyte colony stimulating factorG6PC3, glucose-6-phosphatase C3G6PT, glucose-6-phospate translocaseGSDIb, Glycogen Storage Disease type 1bGlycogen storage disease type 1bM-CSF, macrophage colony stimulating factorMouse modelNET, neutrophil extracellular trapNeutrophilsPMA, phorbol myristate acetatePRM, parallel reaction monitoringRenal sodium-glucose co-transporter-2SGLT2, sodium-glucose co-transporter-2TM, tamoxifenfMLP, N-formyl-L-methionyl-L-leucyl-phenylalanine
DOI
10.1016/j.ymgmr.2021.100813
PMID
34712576
发布时间
2021-10-30
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Molecular genetics and metabolism reports
2021年29卷
100813页
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