Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery (UPGRADE): a multicentre, double-blind, randomised, placebo-controlled superiority trial.-论文-万方医学网

作者： Sylke,Haal ^[1] ; Maimoena S S,Guman ^[2] ; Thomas C C,Boerlage ^[3] ; Yair I Z,Acherman ^[4] ; L Maurits,de Brauw ^[4] ; Sjoerd,Bruin ^[4] ; Steve M M,de Castro ^[5] ; Jeanin E,van Hooft ^[6] ; Arnold W J M,van de Laar ^[4] ; Daan E,Moes ^[7] ; Manon,Schouten ^[8] ; Ruben,Schouten ^[8] ; Ellert J,van Soest ^[9] ; Ruben N,van Veen ^[5] ; Claire E E,de Vries ^[5] ; Paul,Fockens ^[10] ; Marcel G W,Dijkgraaf ^[11] ; Victor E A,Gerdes ^[2] ; Rogier P,Voermans ^[12]

作者单位： Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands; Department of Internal Medicine, Spaarne Gasthuis, Hoofddorp, Netherlands. ^[1] Department of Internal and Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands; Department of Internal Medicine, Spaarne Gasthuis, Hoofddorp, Netherlands. ^[2] Department of Gastroenterology and Hepatology, UMC Utrecht, Utrecht, Netherlands. ^[3] Department of Surgery, Spaarne Gasthuis, Hoofddorp, Netherlands. ^[4] Department of Surgery, OLVG, Amsterdam, Netherlands. ^[5] Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands. ^[6] Department of Surgery, Dijklander Hospital, Hoorn, Netherlands. ^[7] Department of Surgery, Flevohospital, Almere, Netherlands. ^[8] Department of Gastroenterology and Hepatology, Spaarne Gasthuis, Hoofddorp, Netherlands. ^[9] Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands. ^[10] Department of Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands. ^[11] Department of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, Netherlands. Electronic address: r.p.voermans@amsterdamumc.nl. ^[12]

主题词成年人(Adult);减肥手术(Bariatric Surgery);病例对照研究(Case-Control Studies);利胆药和促胆汁分泌药(Cholagogues and Choleretics);胆结石(Cholelithiasis);双盲法(Double-Blind Method);女(雌)性(Female);胃切除术(Gastrectomy);胃旁路术(Gastric Bypass);人类(Humans);腹腔镜检查(Laparoscopy);男(雄)性(Male);中年人(Middle Aged);荷兰(Netherlands);肥胖症, 病态(Obesity, Morbid);安慰剂(Placebos);手术后并发症(Postoperative Complications);安全(Safety);治疗结果(Treatment Outcome);熊脱氧胆酸(Ursodeoxycholic Acid)

DOI 10.1016/S2468-1253(21)00301-0

PMID 34715031

发布时间 2022-12-05

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Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery (UPGRADE): a multicentre, double-blind, randomised, placebo-controlled superiority trial.

The lancet. Gastroenterology & hepatology

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Ursodeoxycholic acid for the prevention of symptomatic gallstone disease after bariatric surgery (UPGRADE): a multicentre, double-blind, randomised, placebo-controlled superiority trial.

The lancet. Gastroenterology & hepatology

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The lancet. Gastroenterology & hepatology

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