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Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.

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作者: Wei-Yu,Lin [1] ; Sarah E,Fordham [1] ; Eric,Hungate [2] ; Nicola J,Sunter [1] ; Claire,Elstob [1] ; Yaobo,Xu [1] ; Catherine,Park [1] ; Anne,Quante [3] ; Konstantin,Strauch [4] ; Christian,Gieger [3] ; Andrew,Skol [4] ; Thahira,Rahman [4] ; Lara,Sucheston-Campbell [2] ; Junke,Wang [1] ; Theresa,Hahn [5] ; Alyssa I,Clay-Gilmour [5] ; Gail L,Jones [6] ; Helen J,Marr [7] ; Graham H,Jackson [8] ; Tobias,Menne [8] ; Mathew,Collin [8] ; Adam,Ivey [8] ; Robert K,Hills [8] ; Alan K,Burnett [9] ; Nigel H,Russell [10] ; Jude,Fitzgibbon [11] ; Richard A,Larson [12] ; Michelle M,Le Beau [13] ; Wendy,Stock [2] ; Olaf,Heidenreich [2] ; Abrar,Alharbi [2] ; David J,Allsup [1] ; Richard S,Houlston [1] ; Jean,Norden [14] ; Anne M,Dickinson [15] ; Elisabeth,Douglas [16] ; Clare,Lendrem [16] ; Ann K,Daly [16] ; Louise,Palm [16] ; Kim,Piechocki [16] ; Sally,Jeffries [17] ; Martin,Bornhäuser [17] ; Christoph,Röllig [17] ; Heidi,Altmann [18] ; Leo,Ruhnke [19] ; Desiree,Kunadt [20] ; Lisa,Wagenführ [20] ; Heather J,Cordell [20] ; Rebecca,Darlay [20] ; Mette K,Andersen [20] ; Maria C,Fontana [20] ; Giovanni,Martinelli [21] ; Giovanni,Marconi [21] ; Miguel A,Sanz [22] ; José,Cervera [23] ; Inés,Gómez-Seguí [24] ; Thomas,Cluzeau [24] ; Chimène,Moreilhon [24] ; Sophie,Raynaud [25] ; Heinz,Sill [26] ; Maria Teresa,Voso [25] ; Francesco,Lo-Coco [26] ; Hervé,Dombret [25] ; Meyling,Cheok [26] ; Claude,Preudhomme [27] ; Rosemary E,Gale [27] ; David,Linch [27] ; Julia,Gaal-Wesinger [28] ; Andras,Masszi [29] ; Daniel,Nowak [29] ; Wolf-Karsten,Hofmann [30] ; Amanda,Gilkes [31] ; Kimmo,Porkka [31] ; Jelena D,Milosevic Feenstra [32] ; Robert,Kralovics [32] ; David,Grimwade [33] ; Manja,Meggendorfer [34] ; Torsten,Haferlach [35] ; Szilvia,Krizsán [35] ; Csaba,Bödör [36] ; Friedrich,Stölzel [37] ; Kenan,Onel [38] ; James M,Allan [38]
作者单位: Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. [1] Section of Pediatric Hematology and Oncology, University of Chicago, Chicago, IL, USA. [2] Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [3] Ludwig-Maximilians-Universität München, Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Munich, Germany. [4] College of Pharmacy, The Ohio State University, Columbus, OH, USA. [5] Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA. [6] Arnold School of Public Health, Department of Epidemiology & Biostatistics, University of South Carolina, Greenville, USA. [7] Department of Haematology, Freeman Hospital, Newcastle upon Tyne Hospitals National Health Service Foundation Trust, Newcastle upon Tyne, UK. [8] Department of Medical and Molecular Genetics, King's College Medical School, London, UK. [9] Nuffield Department of Population Health, University of Oxford, Oxford, UK. [10] Paul O'Gorman Leukaemia Research Centre, University of Glasgow, Glasgow, UK. [11] Department of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK. [12] Barts Cancer Institute, Queen Mary University of London, London, UK. [13] Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School, Hull, UK. [14] Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK. [15] Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. [16] West Midlands Regional Genetics Laboratory, Birmingham Women's Hospital, Birmingham, UK. [17] Department of Haematological Medicine, The Rayne Institute, King's College London, London, UK. [18] National Center for Tumor Diseases NCT, Partner site Dresden, Dresden, Germany. [19] Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany. [20] Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK. [21] Department of Clinical Genetics, University Hospital Rigshospitalet, Copenhagen, Denmark. [22] Institute of Hematology "L. and A. Seràgnoli", University of Bologna, Bologna, Italy. [23] IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy. [24] Hematology Service, Hospital Universitario y Politécnico La Fe, Valencia, Spain. [25] CIBERONC, Instituto de Salud Carlos III, Madrid, Spain. [26] Hematology department, Cote d'Azur University, CHU of Nice, Nice, France. [27] Division of Hematology, Medical University of Graz, Graz, Austria. [28] Università di Roma Tor Vergata, Dipartimento di Biomedicina e Prevenzione, Rome, Italy. [29] Hôpital Saint-Louis, Institut Universitaire d'Hématologie, Université Paris Diderot, Paris, France. [30] Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000, Lille, France. [31] Department of Haematology, University College London Cancer Institute, London, UK. [32] 1st Department of Internal Medicine, Semmewleis University, Budapest, Hungary. [33] 3rd Department of Internal Medicine, Semmewleis University, Budapest, Hungary. [34] Department of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. [35] Department of Haematology, University of Cardiff, Cardiff, UK. [36] Helsinki University Hospital Comprehensive Cancer Center, Hematology Research Unit Helsinki, University of Helsinki, Helsinki, Finland. [37] Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria. [38] MLL Munich Leukemia Laboratory, Munich, Germany. [39] HCEMM-SE Molecular Oncohematology Research Group, 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, Hungary. [40] Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus Dresden, Technical University of Dresden, Dresden, Germany. friedrich.stoelzel@uniklinikum-dresden.de. [41] Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. kenan.onel@mssm.edu. [42] Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. james.allan@newcastle.ac.uk. [43]
DOI 10.1038/s41467-021-26551-x
PMID 34716350
发布时间 2024-02-10
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