An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer.

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作者： Sandra D,Scherer ^[1] ; Alessandra I,Riggio ^[2] ; Fadi,Haroun ^[1] ; Yoko S,DeRose ^[2] ; H Atakan,Ekiz ^[1] ; Maihi,Fujita ^[2] ; Jennifer,Toner ^[1] ; Ling,Zhao ^[2] ; Zheqi,Li ^[1] ; Steffi,Oesterreich ^[2] ; Ahmed A,Samatar ^[1] ; Alana L,Welm ^[2]

作者单位： Department of Oncological Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA. ^[1] Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA. ^[2] Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Women's Research Institute, University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA, 15213, USA. ^[3] Zentalis Pharmaceuticals, Inc., 10835 Road to the Cure, Suite 205, San Diego, CA, 92121, USA. ^[4] Department of Oncological Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA. alana.welm@hci.utah.edu. ^[5] Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA. alana.welm@hci.utah.edu. ^[6]

关键词 Breast cancer tumor microenvironment ER+ PDX ER+ metastatic breast cancer ESR1 mutation Endocrine resistance model Estrogen supplementation Humanized PDX Immune-humanization Y537S