N<sup>1</sup>-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.-论文-万方医学网

第一作者： Yanying,Wang

第一单位： CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China. wangyanying@moon.ibp.ac.cn.

作者： Yanying,Wang ^[1] ; Jing,Wang ^[2] ; Xiaoyu,Li ^[3] ; Xushen,Xiong ^[3] ; Jianyi,Wang ^[2] ; Ziheng,Zhou ^[2] ; Xiaoxiao,Zhu ^[4] ; Yang,Gu ^[2] ; Dan,Dominissini ^[5] ; Lei,He ^[6] ; Yong,Tian ^[7] ; Chengqi,Yi ^[8] ; Zusen,Fan ^[9]

作者单位： CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China. wangyanying@moon.ibp.ac.cn. ^[1] CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China. ^[2] State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. ^[3] CAS Key Laboratory of RNA Biology; Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China. ^[4] University of Chinese Academy of Sciences, 100049, Beijing, China. ^[5] Cancer Research Center and Wohl Institute for Translational Medicine, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6997801, Tel Aviv, Israel. ^[6] Department of Hepatobiliary Surgery, PLA General Hospital, 100853, Beijing, China. ^[7] CAS Key Laboratory of RNA Biology; Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China. ytian@ibp.ac.cn. ^[8] University of Chinese Academy of Sciences, 100049, Beijing, China. ytian@ibp.ac.cn. ^[9] State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China. chengqi.yi@pku.edu.cn. ^[10] CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China. fanz@moon.ibp.ac.cn. ^[11] University of Chinese Academy of Sciences, 100049, Beijing, China. fanz@moon.ibp.ac.cn. ^[12]

主题词腺苷(Adenosine);动物(Animals);癌, 肝细胞(Carcinoma, Hepatocellular);细胞系, 肿瘤(Cell Line, Tumor);胆固醇(Cholesterol);疾病模型, 动物(Disease Models, Animal);女(雌)性(Female);人类(Humans);肝肿瘤(Liver Neoplasms);男(雄)性(Male);膜蛋白质类(Membrane Proteins);甲基化(Methylation);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);中年人(Middle Aged);肿瘤干细胞(Neoplastic Stem Cells);PPARγ(PPAR gamma);RNA, 转移(RNA, Transfer);存活率(Survival Rate);tRNA甲基转移酶类(tRNA Methyltransferases)

DOI 10.1038/s41467-021-26718-6

PMID 34728628

发布时间 2024-04-04

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N<sup>1</sup>-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.

Nature communications

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N<sup>1</sup>-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.

Nature communications

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Nature communications

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