换一批<i>Salmonella</i> flagella confer anti-tumor immunological effect <i>via</i> activating Flagellin/TLR5 signalling within tumor microenvironment.
第一作者：
Jianxiang,Chen
第一单位：
School of Life Sciences, Nanjing University, Nanjing 210023, China.;College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou 311100, China.;Department of Hepatology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou 311121, China.
作者：
关键词
AKT, Akt serine/threonine kinaseBacteria-mediated cancer therapyCFU, colony-forming unitsCTLA-4, cytotoxic T-lymphocyte-associated protein 4Cancer immune therapyDN, dominant-negativeERBB2, Erb-B2 receptor tyrosine kinase 2ERKl, extracellular regulated protein kinase 1FlagellinFlagellumGAPDH, glyceraldehyde-3-phosphate dehydrogenaseGFP, green fluorescent proteinIFN-γ, interferon-γIL, interleukinsIκB, inhibitor of NF-κBJNK, c-Jun N-terminal kinaseLPS, lipopolysaccharideLRR, leucine-rich repeatMyD88, myeloid differentiation factor 88NF-κBNF-κB, nuclear factor kappa-BPBS, phosphate-buffered salinePCR, polymerase chain reactionPD-1, programmed cell death protein-1PD-L1, programmed cell death-ligand 1PEI, polyethylenimineSalmonellaTIR, Toll/Interleukin-1 receptorTLR, Toll-like receptorTLR5TME, tumor microenvironmentTRAF6, TNF receptor associated factor 6VNP20009i.p., intraperitoneallyi.t., intratumorally
DOI
10.1016/j.apsb.2021.04.019
PMID
34729307
发布时间
2021-11-05
- 浏览2
Acta pharmaceutica Sinica. B
2021年11卷10期
3165-3177页
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