换一批Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218.
第一作者：
Po,Hu
第一单位：
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.
作者：
关键词
AO, acridine orangeATG, autophagy relatedBAF A1, bafilomycin A1BID, BH3-interacting domain death agonistCCK8, Cell Counting KitCTSB, cathepsin BCTSD, cathepsin DCaN, calcineurinCathepsin DCholesterolCsA, cyclosporine ADAPI, 4′,6-diamidino-2-phenylindole dihydrochlorideDCFH-DA, 2,7-dichlorodi-hydrofluorescein diacetateDex, dexamethasoneEGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acidFBS, fetal bovine serumHematological malignanciesK48, lysine 48K63, lysine 63LAMPs, lysosomal-associated membrane proteinsLC3, microtubule-associated protein 1 light chain 3LCD, lysosome-dependent cell deathLMP, lysosome membrane permeabilizationLW-218LysophagyLysosomal damageLysosomal membrane permeabilizationLysosome-dependent cell deathNH4Cl, ammonium chlorideNPC, Niemann-Pick type disease CNPC1, NPC intracellular cholesterol transporter 1OD, optical densityP62/SQSTM1, sequestosome 1PBMCs, peripheral blood mononuclear cellsPBS, phosphate-buffered salineRAB7A, RAS-related protein RAB-7aROS, reactive oxygen speciesRT-qPCR, real time quantitative PCRTFEB, transcription factor EBTRPML1, transient receptor potential mucolipin 1shRNA, short hairpin RNA
DOI
10.1016/j.apsb.2021.02.004
PMID
34729308
发布时间
2024-08-17
- 浏览4
Acta pharmaceutica Sinica. B
2021年11卷10期
3178-3192页
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