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Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3.

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第一作者: Tian,Lu
第一单位: School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.;The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
作者: Tian,Lu [1] ; Yong,Li [2] ; Wenchao,Lu [3] ; Twgm,Spitters [4] ; Xueyu,Fang [4] ; Jun,Wang [5] ; Simian,Cai [4] ; Jing,Gao [6] ; Yanting,Zhou [6] ; Zhe,Duan [7] ; Huan,Xiong [8] ; Liping,Liu [9] ; Qi,Li [9] ; Hualiang,Jiang [9] ; Kaixian,Chen [10] ; Hu,Zhou [6] ; Hua,Lin [9] ; Huijin,Feng [11] ; Bing,Zhou [12] ; Christopher L,Antos [4] ; Cheng,Luo [13]
作者单位: School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.;The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. [1] The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. [2] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. [3] School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. [4] School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China. [5] Department of Analytical Chemistry and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. [6] The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;School of Pharmacy, Nanchang University, Nanchang 330006, China. [7] Pharmacological and Toxicological Chemistry and Biochemistry Laboratory, UMR 8601 CNRS, University of Paris, Paris Cedex 06, 75270, France. [8] The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. [9] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.;The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. [10] Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. [11] Department of Medicinal Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. [12] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China.;The Center for Chemical Biology, Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.;School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China. [13]
DOI 10.1016/j.apsb.2021.04.015
PMID 34729310
发布时间 2021-11-05
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Acta pharmaceutica Sinica. B

Acta pharmaceutica Sinica. B

2021年11卷10期

3206-3219页

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