Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy.
作者:
关键词
ALP, alkaline phosphatiseALT, alanine transaminaseAST, aspartate aminotransferaseATP, adenosine triphosphateBUN, blood urea nitrogenCDT, chemodynamic therapyCLSM, confocal laser scanning microscopeCREA, creatinineCRT, calreticulinCTLA-4, cytotoxic T-lymphocyte-associated protein 4CTLs, cytotoxic T lymphocytesCancer immunotherapyCe6, Chlorin e6DAMPs, damage-related molecular patternsDAPI, 2-(4-amidinophenyl)-6-indolecarbamidine dihydrochlorideDCs, dendritic cellsDLS, dynamic light scatteringDMPO, dimethyl pyridine N-oxideEDC, 1-ethyl-3-(3?-dimethylaminopropyl) carbodiimideEDS, energy-dispersive spectrometryEPR, enhanced permeability and retentionESR, electron spin resonanceFG, FeS-GOx nanodotsFGP, FeS-GOx@PTX nanoparticlesFITC, fluorescein IsothiocyanateFeCl2·4H2O, iron dichloride tetrahydrateFeS-based cascade bioreactorGOx, glucose oxidaseGlu, glucoseGlucose oxidaseH&E, hematoxylin and eosinH2DCFDA, 2,7-dichlorodihydrofluorescein acetoacetic acidHMGB-1, high mobility group box protein 1HPF, 2-[6-(4,-hydroxy) phenoxy-3H-xanthene-3-on-9-ylHSA, human serum albuminICB, immune checkpoint blockadeICD amplifierICD, immunogenic cell deathIFN-γ, interferon-γMB, methylene blueMCTS, multicellular tumor spheroidsMFI, median fluorescence IntensityMetastasis inhibitionNHS, N-hydroxy succinimideNa2S, sodium sulfideOH, hydroxylPBS, phosphate buffer salinePTT, photothermal therapyPTX, paclitaxelROS, reactive oxygen speciesSEM, scanning electron microscopeSynergistic therapyTAA, tumor-associated antigensTDLN, tumor-draining lymph nodesTEM, transmission microscopeTMB, 3,3?,5,5?-tetramathylbenzidineTUNEL, terminal deoxynucleotidyl transferase dUTP nick end labellingTumor penetrationXPS, X-ray photoelectron spectroscopyXRD, X-ray diffraction patterns
DOI
10.1016/j.apsb.2021.05.005
PMID
34729313
发布时间
2021-11-05
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Acta pharmaceutica Sinica. B
2021年11卷10期
3244-3261页
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