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Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to <i>TTN</i> mutations.

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作者单位: Clinic for Cardiology and Pneumology, University Medical Center, 37075 Göttingen, Germany. [1] German Centre for Cardiovascular Research, 10785 Berlin, partner site Göttingen, Germany. [2] Erich and Hanna Klessmann Institute, Heart and Diabetes Centre NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany. [3] Stem Cell Unit, University Medical Center, 37075 Göttingen, Germany. [4] Institute of Pharmacology and Toxicology, University Medical Center, 37075 Göttingen, Germany. [5] Department of Cardiology I, Coronary, Peripheral Vascular Disease and Heart Failure, 48149 University Hospital Münster, Münster, Germany. [6] Institute of Physiology II, University of Münster, 48149 Münster, Germany. [7] First Medical Department, Cardiology, Technical University of Munich, 81675 Munich, Germany. [8] German Centre for Cardiovascular Research, 10785 Berlin, partner site Munich, Germany. [9] Department of Cell and Molecular Biology, Karolinska Institute, S-17177 Stockholm, Sweden. [10] Munich Heart Alliance, 80802 Munich, Germany. [11] Department of Cardio-Thoracic Surgery, Heart and Diabetes Centre NRW, University Hospital of the Ruhr-University Bochum, 32545 Bad Oeynhausen, Germany. [12] Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia. [13] Department of Medicine, Integrated Cardio Metabolic Centre (ICMC), Heart and Vascular Theme, Karolinska Institute, S-17177 Stockholm, Sweden. [14] Bioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&amp;D, AstraZeneca, 43183 Gothenburg, Sweden. [15] Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany. [16] German Centre for Cardiovascular Research, 10785 Berlin, partner site Berlin, Germany. [17] Princess Máxima Center for Pediatric Oncology, 3584 CT Utrecht, Netherlands. [18] Charité-Universitätsmedizin, 10117 Berlin, Germany. [19] Berlin Institute of Health, 10178 Berlin, Germany. [20] Cluster of Excellence "Multiscale Bioimaging: From Molecular Machines to Networks of Excitable Cells," University of Göttingen, 37073 Göttingen, Germany. [21]
DOI 10.1126/scitranslmed.abd3079
PMID 34731013
发布时间 2022-05-31
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