FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistance.

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作者： Yihao,Li ^[1] ; Xintao,Qiu ^[2] ; Xiaoqing,Wang ^[1] ; Hui,Liu ^[2] ; Renee C,Geck ^[1] ; Alok K,Tewari ^[2] ; Tengfei,Xiao ^[3] ; Alba,Font-Tello ^[3] ; Klothilda,Lim ^[1] ; Kristen L,Jones ^[2] ; Murry,Morrow ^[1] ; Raga,Vadhi ^[2] ; Pei-Lun,Kao ^[1] ; Aliya,Jaber ^[2] ; Smitha,Yerrum ^[1] ; Yingtian,Xie ^[2] ; Kin-Hoe,Chow ^[4] ; Paloma,Cejas ^[4] ; Quang-Dé,Nguyen ^[1] ; Henry W,Long ^[2] ; X Shirley,Liu ^[5] ; Alex,Toker ^[6] ; Myles,Brown ^[5]

作者单位： Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. ^[1] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. ^[2] Department of Pathology, and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. ^[3] Lurie Family Imaging Center, Center for Biomedical Imaging in Oncology, Dana-Farber Cancer Institute, Boston, Boston, MA, USA. ^[4] Department of Oncologic Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. ^[5] Center for Patient Derived Models, Dana-Farber Cancer Institute, Boston, MA, USA. ^[6] Department of Data Science, Dana-Farber Cancer Institute, Harvard T.H. Chan School of Public Health, Boston, MA, USA. ^[7] Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. ^[8] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. myles_brown@dfci.harvard.edu. ^[9] Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA. myles_brown@dfci.harvard.edu. ^[10] Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA. myles_brown@dfci.harvard.edu. ^[11]