A multi-omic single-cell landscape of human gynecologic malignancies.

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第一作者： Matthew J,Regner

第一单位： Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Bioinformatics and Computational Biology Graduate Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

作者： Matthew J,Regner ^[1] ; Kamila,Wisniewska ^[2] ; Susana,Garcia-Recio ^[2] ; Aatish,Thennavan ^[3] ; Raul,Mendez-Giraldez ^[2] ; Venkat S,Malladi ^[4] ; Gabrielle,Hawkins ^[5] ; Joel S,Parker ^[6] ; Charles M,Perou ^[7] ; Victoria L,Bae-Jump ^[8] ; Hector L,Franco ^[9]

作者单位： Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Bioinformatics and Computational Biology Graduate Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[1] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[2] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Oral and Craniofacial Biomedicine Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[3] Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ^[4] Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[5] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[6] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[7] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. ^[8] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Bioinformatics and Computational Biology Graduate Program, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: hfranco@med.unc.edu. ^[9]

关键词 chromatin accessibility endometrial cancer enhancer elements gastro-intestinal stromal tumors gene regulation intratumoral heterogeneity ovarian cancer scATAC-seq scRNA-seq single-cell genomics