首页> Nature communications> Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM.

Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM.

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第一作者： Lynn,Radamaker

第一单位： Institute of Protein Biochemistry, Ulm University, 89081, Ulm, Germany.

作者： Lynn,Radamaker ^[1] ; Sara,Karimi-Farsijani ^[1] ; Giada,Andreotti ^[1] ; Julian,Baur ^[1] ; Matthias,Neumann ^[2] ; Sarah,Schreiner ^[3] ; Natalie,Berghaus ^[3] ; Raoul,Motika ^[4] ; Christian,Haupt ^[1] ; Paul,Walther ^[5] ; Volker,Schmidt ^[2] ; Stefanie,Huhn ^[3] ; Ute,Hegenbart ^[6] ; Stefan O,Schönland ^[6] ; Sebastian,Wiese ^[7] ; Clarissa,Read ^[8] ; Matthias,Schmidt ^[1] ; Marcus,Fändrich ^[9]

作者单位： Institute of Protein Biochemistry, Ulm University, 89081, Ulm, Germany. ^[1] Institute of Stochastics, Ulm University, 89081, Ulm, Germany. ^[2] Medical Department V, Section of Multiple Myeloma, Heidelberg University Hospital, 69120, Heidelberg, Germany. ^[3] Department of Asia-Africa-Studies, Middle Eastern History and Culture, University of Hamburg, 20148, Hamburg, Germany. ^[4] Central Facility for Electron Microscopy, Ulm University, 89081, Ulm, Germany. ^[5] Medical Department V, Amyloidosis Center, Heidelberg University Hospital, 69120, Heidelberg, Germany. ^[6] Core Unit Mass Spectrometry and Proteomics, Medical Faculty, Ulm University, 89081, Ulm, Germany. ^[7] Central Facility for Electron Microscopy, Ulm University, 89081, Ulm, Germany.;Institute of Virology, Ulm University Medical Center, 89081, Ulm, Germany. ^[8] Institute of Protein Biochemistry, Ulm University, 89081, Ulm, Germany. marcus.faendrich@uni-ulm.de. ^[9]

医学主题词冷冻电子显微镜检查(Cryoelectron Microscopy);糖基化(Glycosylation);突变(Mutation);蛋白质构象(Protein Conformation);蛋白质折叠(Protein Folding)

DOI 10.1038/s41467-021-26553-9

PMID 34741031

发布时间 2023-11-02

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