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首页> European journal of medicinal chemistry> Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.

Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model.

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作者： Hongrui,Lei ^[1] ; Zhi,Cao ^[1] ; Huinan,Wu ^[1] ; Tong,Li ^[1] ; Xinyu,Wang ^[1] ; Yuxiang,Chen ^[1] ; Enlong,Ma ^[2] ; Lixin,Sun ^[3] ; Xin,Zhai ^[4]

作者单位： Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. ^[1] Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: maenlong@hotmail.com. ^[2] School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: sunlixin67@yahoo.com. ^[3] Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: zhaixin_syphu@126.com. ^[4]

关键词 Antifibrosis Carbamate/urea linker Computational analysis Indole-based ATX inhibitors PK

主题词动物(Animals);疾病模型, 动物(Disease Models, Animal);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);吲哚类(Indoles);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);分子结构(Molecular Structure);磷酸二酯水解酶类(Phosphoric Diester Hydrolases);肺纤维化(Pulmonary Fibrosis);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2021.113951

PMID 34742015

发布时间 2022-01-25

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European journal of medicinal chemistry

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