首页> Journal of hematology & oncology> VEGF pathway inhibition potentiates PARP inhibitor efficacy in ovarian cancer independent of BRCA status.

VEGF pathway inhibition potentiates PARP inhibitor efficacy in ovarian cancer independent of BRCA status.

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第一作者： Francesca,Bizzaro

第一单位： Laboratory of Cancer Metastasis Therapeutics, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy.

作者： Francesca,Bizzaro ^[1] ; Ilaria,Fuso Nerini ^[2] ; Molly A,Taylor ^[3] ; Alessia,Anastasia ^[1] ; Massimo,Russo ^[1] ; Giovanna,Damia ^[4] ; Federica,Guffanti ^[4] ; Francesca,Guana ^[5] ; Paola,Ostano ^[5] ; Lucia,Minoli ^[6] ; Maureen M,Hattersley ^[7] ; Stephanie,Arnold ^[3] ; Antonio,Ramos-Montoya ^[3] ; Stuart C,Williamson ^[3] ; Alessandro,Galbiati ^[3] ; Jelena,Urosevic ^[3] ; Elisabetta,Leo ^[3] ; Ugo,Cavallaro ^[8] ; Carmen,Ghilardi ^[1] ; Simon T,Barry ^[3] ; Maria Rosa,Bani ^[9] ; Raffaella,Giavazzi ^[1]

作者单位： Laboratory of Cancer Metastasis Therapeutics, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy. ^[1] Laboratory of Cancer Metastasis Therapeutics, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy.;Laboratory of Cancer Pharmacology, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy. ^[2] Early Oncology, AstraZeneca, Cambridge, UK. ^[3] Laboratory of Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy. ^[4] Laboratory of Cancer Genomics, Fondazione Edo ed Elvo Tempia Valenta, Biella, Italy. ^[5] Department of Veterinary Medicine, University of Milan, Milan, Italy. ^[6] Early Oncology, AstraZeneca, Boston, USA. ^[7] Unit of Gynecological Oncology Research, Istituto Europeo di Oncologia IRCCS, Milan, Italy. ^[8] Laboratory of Cancer Metastasis Therapeutics, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156, Milan, Italy. mariarosa.bani@marionegri.it. ^[9]

关键词 BRCA Cediranib Olaparib Ovarian cancer PARP inhibitor Patient-derived xenograft VEGF pathway inhibitor