REGEN-COV<sup>®</sup> antibody cocktail bioanalytical strategy: comparison of LC-MRM-MS and immunoassay methods for drug quantification.

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作者： Susan C,Irvin ^[1] ; Samit,Ganguly ^[2] ; Rachel,Weiss ^[1] ; Chinnasamy,Elango ^[1] ; Xuefei,Zhong ^[3] ; Yuan,Mao ^[3] ; Hong,Yan ^[2] ; Ning,Li ^[3] ; Giane,Sumner ^[1] ; Kenneth C,Turner ^[2] ; John D,Davis ^[2] ; A Thomas,DiCioccio ^[2] ; Matthew D,Andisik ^[1] ; Michael A,Partridge ^[1] ; Albert,Torri ^[1]

作者单位： Regeneron Pharmaceuticals, Bioanalytical Sciences, 777 Old Saw Mill River Rd, Tarrytown, NY 10591, USA. ^[1] Regeneron Pharmaceuticals, Pharmacometrics, 777 Old Saw Mill River Rd, Tarrytown, NY 10591, USA. ^[2] Regeneron Pharmaceuticals, Analytical Chemistry, 777 Old Saw Mill River Rd, Tarrytown, NY 10591, USA. ^[3]

关键词 Bland-Altman SARS-CoV-2 bioanalytical drug concentration assay monoclonal antibody therapeutic

主题词抗体, 单克隆(Antibodies, Monoclonal);色谱法, 液相(Chromatography, Liquid);电化学技术(Electrochemical Techniques);人类(Humans);发光(Luminescence);质谱分析法(Mass Spectrometry)

DOI 10.4155/bio-2021-0190

PMID 34743612

发布时间 2021-12-14

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准确一般字义偏差语意偏离译文作用小提交