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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients.

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作者单位: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. [1] UCI MIND, University of California, Irvine, CA 92697, USA. [2] Center for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes, University of California, San Francisco, San Francisco, CA 94158, USA. [3] The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.;Advanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. [4] Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MA 212056, USA.;Department of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MA 212056, USA. [5] Department of Biological Chemistry, University of California, Irvine, CA 92697, USA. [6] Cellular and Molecular Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MA 212056, USA. [7] The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. [8] UCI MIND, University of California, Irvine, CA 92697, USA.;Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA. [9] Department of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MA 212056, USA. [10] Advanced Clinical Biosystems Research Institute, The Barbra Streisand Heart Center, The Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. [11] Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MA 212056, USA. [12] Sue and Bill Gross Stem Cell Center, University of California, Irvine, CA 92697, USA. [13] Center for Systems and Therapeutics and the Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes, University of California, San Francisco, San Francisco, CA 94158, USA.;Departments of Neurology and Physiology, University of California, San Francisco, San Francisco, CA 94158, USA. [14] Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MA 212056, USA.;Department of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MA 212056, USA.;Cellular and Molecular Medicine Program, Johns Hopkins University School of Medicine, Baltimore, MA 212056, USA. [15] UCI MIND, University of California, Irvine, CA 92697, USA.;Department of Biological Chemistry, University of California, Irvine, CA 92697, USA.;Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.;Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA.;Sue and Bill Gross Stem Cell Center, University of California, Irvine, CA 92697, USA. [16]
DOI 10.1016/j.isci.2021.103221
PMID 34746695
发布时间 2024-08-17
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