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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.

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第一作者： Steven A,Saenz

第一单位： Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America.

作者： Steven A,Saenz ^[1] ; Andrea,Local ^[2] ; Tiffany,Carr ^[1] ; Arvind,Shakya ^[2] ; Shivsmriti,Koul ^[2] ; Haiqing,Hu ^[3] ; Lisa,Chourb ^[3] ; Justin,Stedman ^[3] ; Jenna,Malley ^[4] ; Laura Akullian,D'Agostino ^[5] ; Veerabahu,Shanmugasundaram ^[5] ; John,Malona ^[6] ; C Eric,Schwartz ^[6] ; Lisa,Beebe ^[3] ; Meghan,Clements ^[4] ; Ganesh,Rajaraman ^[4] ; John,Cho ^[7] ; Lan,Jiang ^[1] ; Alex,Dubrovskiy ^[1] ; Matt,Kreilein ^[6] ; Roman,Shimanovich ^[3] ; Lawrence G,Hamann ^[5] ; Laure,Escoubet ^[2] ; J Michael,Ellis ^[5]

作者单位： Immunology, Cardiovascular & Fibrosis, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America. ^[1] Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, California, United States of America. ^[2] Preclinical Candidate Optimization, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America. ^[3] Nonclinical Development, Celgene Corporation, Cambridge, Massachusetts, United States of America. ^[4] Small Molecule Drug Discovery, Bristol Myers Squibb, Cambridge, Massachusetts, United States of America. ^[5] Drug Substance Development, Bristol Myers Squibb, Summit, New Jersey, United States of America. ^[6] Immunology & Inflammation, Celgene Corporation, Cambridge, Massachusetts, United States of America. ^[7]