Mechanistic Investigation of Drug Supersaturation in the Presence of Polysorbates as Solubilizing Additives by Solution Nuclear Magnetic Resonance Spectroscopy.

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作者： Xingyu,Lu ^[1] ; Mingyue,Li ^[2] ; Freddy A,Arce ^[1] ; Jing,Ling ^[3] ; Nico,Setiawan ^[4] ; Yaqiang,Wang ^[3] ; Xiaohuo,Shi ^[5] ; Heather R,Campbell ^[2] ; Matthew J,Nethercott ^[3] ; Wei,Xu ^[6] ; Eric J,Munson ^[1] ; Patrick J,Marsac ^[7] ; Yongchao,Su ^[3]

作者单位： Analytical Research and Development, Merck & Co., Rahway, New Jersey 07065, United States. ^[1] Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province, School of Science, Westlake University, Hangzhou, Zhejiang 310024, China. ^[2] Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States. ^[3] Pharmaceutical Sciences, Merck & Co., South San Francisco, California 94080, United States. ^[4] Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095 United States. ^[5] Kansas Analytical Services, LLC, Loveland, Colorado 80537, United States. ^[6] Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States. ^[7] Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States. ^[8]

关键词 17β-Estradiol NMR drug interaction lipid formulation micelle polysorbate supersaturation surfactant

主题词结晶(Crystallization);雌二醇(Estradiol);磁共振波谱学(Magnetic Resonance Spectroscopy);微胶粒(Micelles);粒子大小(Particle Size);聚山梨醇酯类(Polysorbates);溶解度(Solubility)

DOI 10.1021/acs.molpharmaceut.1c00477

PMID 34761934

发布时间 2022-03-14

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