Single-strand specific nuclease enhances accuracy of error-corrected sequencing and improves rare mutation-detection sensitivity.

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作者： Yuki,Otsubo ^[1] ; Shoji,Matsumura ^[2] ; Naohiro,Ikeda ^[1] ; Masayuki,Yamane ^[3]

作者单位： R&D Safety Science Research, Kao Corporation, 3-25-14 Tono-machi, Kawasaki-ku, Kawasaki City, Kanagawa, 210-0821, Japan. ^[1] R&D Safety Science Research, Kao Corporation, 3-25-14 Tono-machi, Kawasaki-ku, Kawasaki City, Kanagawa, 210-0821, Japan. matsumura.shouji@kao.com. ^[2] R&D Safety Science Research, Kao Corporation, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi, 321-3497, Japan. ^[3]

关键词 End-repair artifacts Error-corrected sequencing Mutagenesis Next-generation sequencing Rare mutation Single-strand specific nuclease

主题词 DNA(DNA);DNA修复(DNA Repair);高通量核苷酸序列分析(High-Throughput Nucleotide Sequencing);诱变剂(Mutagens);突变(Mutation)

DOI 10.1007/s00204-021-03185-y

PMID 34767040

发布时间 2022-04-05

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