Tofacitinib in juvenile idiopathic arthritis: a double-blind, placebo-controlled, withdrawal phase 3 randomised trial.
作者:
Nicolino,Ruperto [1]
;
Hermine I,Brunner [2]
;
Olga,Synoverska [3]
;
Tracy V,Ting [2]
;
Carlos Abud,Mendoza [4]
;
Alberto,Spindler [5]
;
Yulia,Vyzhga [6]
;
Katherine,Marzan [7]
;
Lyudmila,Grebenkina [8]
;
Irit,Tirosh [9]
;
Lisa,Imundo [10]
;
Rita,Jerath [11]
;
Daniel J,Kingsbury [12]
;
Betul,Sozeri [13]
;
Sheetal S,Vora [14]
;
Sampath,Prahalad [15]
;
Elena,Zholobova [16]
;
Yonatan,Butbul Aviel [17]
;
Vyacheslav,Chasnyk [18]
;
Melissa,Lerman [19]
;
Kabita,Nanda [20]
;
Heinrike,Schmeling [21]
;
Heather,Tory [22]
;
Yosef,Uziel [23]
;
Diego O,Viola [24]
;
Holly B,Posner [25]
;
Keith S,Kanik [26]
;
Ann,Wouters [25]
;
Cheng,Chang [26]
;
Richard,Zhang [25]
;
Irina,Lazariciu [25]
;
Ming-Ann,Hsu [26]
;
Ricardo M,Suehiro [27]
;
Alberto,Martini [28]
;
Daniel J,Lovell [2]
;
Paediatric Rheumatology International Trials Organisation (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG)
作者单位:
IRCCS Istituto Giannina Gaslini, UOSID Centro Trial, PRINTO, Genova, Italy. Electronic address: nicolaruperto@gaslini.org.
[1]
College of Medicine, University of Cincinnati, and Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
[2]
Regional Children's Hospital, Ivano-Frankivsk, Ukraine.
[3]
Regional Unit of Rheumatology and Osteoporosis at Central Hospital, Faculty of Medicine, San Luis Potosí, Mexico.
[4]
Centro Médico Privado de Reumatologia, Tucumán, Argentina.
[5]
Vinnytsya National Medical University N Pirogov, Vinnytsya, Ukraine.
[6]
Division of Rheumatology, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[7]
Togliatti City Clinical Hospital number 5, Togliatti, Russia.
[8]
Pediatric Rheumatology Unit and Department of Pediatrics, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
[9]
Adolescent Rheumatology Columbia University Medical Center, New York, NY, USA.
[10]
Augusta University Medical Center, Augusta, GA, USA.
[11]
Augusta University Medical Center, Augusta, GA, USA; Randall Children's Hospital at Legacy Emanuel, Portland, OR, USA.
[12]
Department of Pediatric Rheumatology, Ümraniye Training and Research Hospital, Istanbul, Turkey.
[13]
Pediatric Rheumatology, Atrium Health Levine Children's Hospital, Charlotte, NC, USA.
[14]
Departments of Pediatrics and Human Genetics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Atlanta, GA, USA.
[15]
Institute of Children's Health, University Children's Clinical Hospital, Sechenov University, Moscow, Russia.
[16]
Pediatric Rheumatology Service, Ruth Rappaport Children's Hospital, Rambam Medical Center, Haifa, Israel.
[17]
Saint Petersburg State Pediatric Medical University, Saint-Petersburg, Russia.
[18]
Division of Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
[19]
Division of Rheumatology, Seattle Children's Hospital, Seattle, WA, USA.
[20]
Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada.
[21]
Division of Rheumatology, Connecticut Children's Medical Center, Hartford, and Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA.
[22]
Pediatric Rheumatology Unit, Department of Pediatrics, Meir Medical Centre, Kfar Saba, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
[23]
CAICI Institute, Rosario City, Argentina.
[24]
Pfizer, New York, NY, USA.
[25]
Pfizer, Groton, CT, USA.
[26]
Pfizer, Collegeville, PA, USA.
[27]
Università degli Studi di Genova, Genova, Italy.
[28]
主题词
投药, 口服(Administration, Oral);青少年(Adolescent);儿童(Child);儿童, 学龄前(Child, Preschool);人类(Humans);哌啶类(Piperidines);嘧啶类(Pyrimidines);治疗结果(Treatment Outcome)
DOI
10.1016/S0140-6736(21)01255-1
PMID
34767764
发布时间
2022-05-24
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Lancet (London, England)
Lancet (London, England)
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