Anti-FGFR3 antibody epitopes are functional sites and correlate with the neuropathy pattern.

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作者： Yannick,Tholance ^[1] ; Jean-Christophe,Antoine ^[2] ; Lauriane,Mohr ^[3] ; Martin,Jung ^[4] ; Evelyne,Reynaud-Federspiel ^[3] ; Karine,Ferraud ^[5] ; Jean-Philippe,Camdessanché ^[6] ; Christian P,Moritz ^[7]

作者单位： Synaptopathies and Autoantibodies, Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, University of Lyon, University Jean Monnet, 10 rue de Marandière, 42270 Saint-Priest-en-Jarez, France; Department of Biochemistry, University hospital of Saint-Etienne, Avenue Albert Raimond, 42270 Saint-Priest-en-Jarez, France. Electronic address: Yannick.Tholance@chu-st-etienne.fr. ^[1] Synaptopathies and Autoantibodies, Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, University of Lyon, University Jean Monnet, 10 rue de Marandière, 42270 Saint-Priest-en-Jarez, France; Department of Neurology, University hospital of Saint-Etienne, Avenue Albert Raimond, 42270 Saint-Priest-en-Jarez, France. Electronic address: j.christophe.antoine@chu-st-etienne.fr. ^[2] Synaptopathies and Autoantibodies, Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, University of Lyon, University Jean Monnet, 10 rue de Marandière, 42270 Saint-Priest-en-Jarez, France. ^[3] Medical Biochemistry and Molecular Biology, Saarland University, UKS, 66421 Homburg, Germany. Electronic address: Martin.Jung@uks.eu. ^[4] Department of Neurology, University hospital of Saint-Etienne, Avenue Albert Raimond, 42270 Saint-Priest-en-Jarez, France. Electronic address: karine.ferraud@chu-st-etienne.fr. ^[5] Synaptopathies and Autoantibodies, Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, University of Lyon, University Jean Monnet, 10 rue de Marandière, 42270 Saint-Priest-en-Jarez, France; Department of Neurology, University hospital of Saint-Etienne, Avenue Albert Raimond, 42270 Saint-Priest-en-Jarez, France. Electronic address: j.philippe.camdessanche@chu-st-etienne.fr. ^[6] Synaptopathies and Autoantibodies, Institut NeuroMyoGene INSERM U1217/CNRS UMR 5310, University of Lyon, University Jean Monnet, 10 rue de Marandière, 42270 Saint-Priest-en-Jarez, France; Department of Neurology, University hospital of Saint-Etienne, Avenue Albert Raimond, 42270 Saint-Priest-en-Jarez, France. Electronic address: christian.moritz@univ-st-etienne.fr. ^[7]

关键词 Anti-FGFR3 autoantibody Epitope mapping Immune-mediated neuropathy Peripheral neuropathy Phosphorylation Sensory neuropathy