ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.

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第一作者： Wenbin,Huang

第一单位： Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: hwb1298971713@foxmail.com.

作者： Wenbin,Huang ^[1] ; Kunling,Chen ^[2] ; Yishi,Lu ^[3] ; Donghui,Zhang ^[4] ; Yuan,Cheng ^[5] ; Liuran,Li ^[6] ; Weimei,Huang ^[7] ; Guolin,He ^[8] ; Hangyu,Liao ^[9] ; Lei,Cai ^[10] ; Yujun,Tang ^[11] ; Liang,Zhao ^[12] ; Mingxin,Pan ^[13]

作者单位： Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: hwb1298971713@foxmail.com. ^[1] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: 1987454446@qq.com. ^[2] Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: louis_ann@163.com. ^[3] Department of Pathology, Affiliated Tumor Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address: 18819129896@163.com. ^[4] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: chengyuan9226@sohu.com. ^[5] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: 1012139428@qq.com. ^[6] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: weimei135gx@163.com. ^[7] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: dwtou@126.com. ^[8] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: Lhymarc@163.com. ^[9] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: cailei_427@163.com. ^[10] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: tangyujun1994@sohu.com. ^[11] Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China. Electronic address: liangsmu@foxmail.com. ^[12] Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: pmxwxy@sohu.com. ^[13]

关键词 ABCC5 Acquired resistance Ferroptosis Hepatocellular carcinoma Sorafenib

主题词氨基酸转运系统y+(Amino Acid Transport System y+);癌, 肝细胞(Carcinoma, Hepatocellular);细胞系, 肿瘤(Cell Line, Tumor);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);肝肿瘤(Liver Neoplasms);多药耐药相关蛋白质类(Multidrug Resistance-Associated Proteins)

DOI 10.1016/j.neo.2021.11.002

PMID 34768109

发布时间 2022-03-04

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