Human Recombinant DNase I (Pulmozyme<sup>®</sup>) Inhibits Lung Metastases in Murine Metastatic B16 Melanoma Model That Correlates with Restoration of the DNase Activity and the Decrease SINE/LINE and c-Myc Fragments in Blood Cell-Free DNA.
第一作者:
Ludmila,Alekseeva
第一单位:
Institute of Chemical Biology and Fundamental Medicine SB RAS, Lavrentiev ave., 8, 630090 Novosibirsk, Russia.
作者:
医学主题词
动物(Animals);细胞系, 肿瘤(Cell Line, Tumor);脱氧核糖核酸酶Ⅰ(Deoxyribonuclease I);疾病模型, 动物(Disease Models, Animal);药物重新定位(Drug Repositioning);长核苷酸元件(Long Interspersed Nucleotide Elements);肺肿瘤(Lung Neoplasms);男(雄)性(Male);黑色素瘤, 实验性(Melanoma, Experimental);小鼠(Mice);原癌基因蛋白质c-myc(Proto-Oncogene Proteins c-myc);重组蛋白质类(Recombinant Proteins);短分散核苷酸元件(Short Interspersed Nucleotide Elements)
DOI
10.3390/ijms222112074
PMID
34769514
发布时间
2022-01-11
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