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Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis.

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第一作者： Ann-Marie,Mallon

第一单位： MRC Harwell Institute, Harwell Campus, Oxfordshire, OX11 0RD, UK. a.mallon@har.mrc.ac.uk.

作者： Ann-Marie,Mallon ^[1] ; Dieter A,Häring ^[2] ; Frank,Dahlke ^[2] ; Piet,Aarden ^[2] ; Soroosh,Afyouni ^[3] ; Daniel,Delbarre ^[4] ; Khaled,El Emam ^[5] ; Habib,Ganjgahi ^[6] ; Stephen,Gardiner ^[4] ; Chun Hei,Kwok ^[4] ; Dominique M,West ^[4] ; Ewan,Straiton ^[4] ; Sibylle,Haemmerle ^[2] ; Adam,Huffman ^[3] ; Tom,Hofmann ^[2] ; Luke J,Kelly ^[7] ; Peter,Krusche ^[2] ; Marie-Claude,Laramee ^[2] ; Karine,Lheritier ^[2] ; Greg,Ligozio ^[8] ; Aimee,Readie ^[8] ; Luis,Santos ^[4] ; Thomas E,Nichols ^[3] ; Janice,Branson ^[2] ; Chris,Holmes ^[6]

作者单位： MRC Harwell Institute, Harwell Campus, Oxfordshire, OX11 0RD, UK. a.mallon@har.mrc.ac.uk. ^[1] Novartis Pharma AG, Basel, Switzerland. ^[2] Big Data Institute, University of Oxford Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford, OX3 7LF, UK. ^[3] MRC Harwell Institute, Harwell Campus, Oxfordshire, OX11 0RD, UK. ^[4] Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, Ontario, K1J 8 L1, Canada. ^[5] Department of Statistics, University of Oxford, 24-29 St Giles', OX1 3LB, Oxford, UK. ^[6] Big Data Institute, University of Oxford Li Ka Shing Centre for Health Information and Discovery, Old Road Campus, Oxford, OX3 7LF, UK.;Department of Statistics, University of Oxford, 24-29 St Giles', OX1 3LB, Oxford, UK. ^[7] Novartis Pharma AG, East Hanover, NJ, USA. ^[8]

关键词 Clinical trial Data anonymisation Data management Machine learning

医学主题词数据库, 事实型(Databases, Factual);人类(Humans);信息传播(Information Dissemination);研究设计(Research Design)

DOI 10.1186/s12874-021-01409-4

PMID 34773974

发布时间 2021-11-23

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