Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition.

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作者： Masakazu,Niimi ^[1] ; Kyoko,Niimi ^[1] ; Koichi,Tanabe ^[2] ; Richard D,Cannon ^[1] ; Erwin,Lamping ^[1]

作者单位： Sir John Walsh Research Institute, University of Otagogrid.29980.3a, Dunedin, New Zealand. ^[1] Department of Food Science and Human Nutrition, Faculty of Agriculture, Ryukoku University, Shiga, Japan. ^[2]

关键词 ABC transporter Candida albicans Cdr1 PDR transporter drug resistance efflux pump inhibitors kinetics transport cycle

主题词 ATP结合匣式转运子(ATP-Binding Cassette Transporters);抗真菌药(Antifungal Agents);白色念珠菌(Candida albicans);抗药性, 真菌(Drug Resistance, Fungal);氟康唑(Fluconazole);真菌蛋白质类(Fungal Proteins);膜转运蛋白质类(Membrane Transport Proteins);底物特异性(Substrate Specificity)

DOI 10.1128/AAC.01748-21

PMID 34780272

发布时间 2022-03-22

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Antimicrobial agents and chemotherapy

2022年66卷1期

e0174821页

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Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition.

Antimicrobial agents and chemotherapy

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Antimicrobial agents and chemotherapy

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Inhibitor-Resistant Mutants Give Important Insights into Candida albicans ABC Transporter Cdr1 Substrate Specificity and Help Elucidate Efflux Pump Inhibition.

Antimicrobial agents and chemotherapy

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Antimicrobial agents and chemotherapy

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