An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice.
作者:
Etsuro,Nanishi [1]
;
Francesco,Borriello [2]
;
Timothy R,O'Meara [1]
;
Marisa E,McGrath [2]
;
Yoshine,Saito [3]
;
Robert E,Haupt [1]
;
Hyuk-Soo,Seo [4]
;
Simon D,van Haren [1]
;
Cecilia B,Cavazzoni [4]
;
Byron,Brook [5]
;
Soumik,Barman [6]
;
Jing,Chen [1]
;
Joann,Diray-Arce [2]
;
Simon,Doss-Gollin [7]
;
Maria,De Leon [1]
;
Alejandra,Prevost-Reilly [2]
;
Katherine,Chew [1]
;
Manisha,Menon [2]
;
Kijun,Song [8]
;
Andrew Z,Xu [1]
;
Timothy M,Caradonna [2]
;
Jared,Feldman [1]
;
Blake M,Hauser [1]
;
Aaron G,Schmidt [1]
;
Amy C,Sherman [1]
;
Lindsey R,Baden [1]
;
Robert K,Ernst [5]
;
Carly,Dillen [5]
;
Stuart M,Weston [9]
;
Robert M,Johnson [9]
;
Holly L,Hammond [9]
;
Romana,Mayer [9]
;
Allen,Burke [10]
;
Maria E,Bottazzi [1]
;
Peter J,Hotez [11]
;
Ulrich,Strych [11]
;
Aiquan,Chang [12]
;
Jingyou,Yu [4]
;
Peter T,Sage [4]
;
Dan H,Barouch [4]
;
Sirano,Dhe-Paganon [4]
;
Ivan,Zanoni [13]
;
Al,Ozonoff [13]
;
Matthew B,Frieman [14]
;
Ofer,Levy [15]
;
David J,Dowling [14]
作者单位:
Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA 02115, USA.
[1]
Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
[2]
Division of Immunology, Boston Children's Hospital, Boston, MA 02115, USA.
[3]
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
[4]
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
[5]
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
[6]
Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
[7]
Research Computing Group, Boston Children's Hospital, Boston, MA 02115, USA.
[8]
Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA.
[9]
Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.
[10]
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
[11]
Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
[12]
Department of Pathology, University of Maryland Medical Center, Baltimore, MD 21201, USA.
[13]
Texas Children's Hospital Center for Vaccine Development, Baylor College of Medicine, Houston, TX 77030, USA.
[14]
National School of Tropical Medicine and Departments of Pediatrics and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.
[15]
National School of Tropical Medicine and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
[16]
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
[17]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
[18]
主题词
老年人(Aged);氢氧化铝(Aluminum Hydroxide);动物(Animals);抗体, 中和(Antibodies, Neutralizing);抗体, 病毒(Antibodies, Viral);人类(Humans);小鼠(Mice);疾病大流行(Pandemics);疫苗, 合成(Vaccines, Synthetic)
DOI
10.1126/scitranslmed.abj5305
PMID
34783582
发布时间
2024-03-02
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Science translational medicine
Science translational medicine
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