NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome.

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第一作者： Tatsuaki,Kurosaki

第一单位： Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.;Center for RNA Biology, University of Rochester, Rochester, NY, 14642, USA.

作者： Tatsuaki,Kurosaki ^[1] ; Hitomi,Sakano ^[2] ; Christoph,Pröschel ^[3] ; Jason,Wheeler ^[4] ; Alexander,Hewko ^[1] ; Lynne E,Maquat ^[5]

作者单位： Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.;Center for RNA Biology, University of Rochester, Rochester, NY, 14642, USA. ^[1] Center for RNA Biology, University of Rochester, Rochester, NY, 14642, USA. Hitomi_Sakano@urmc.rochester.edu.;Department of Otolaryngology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. Hitomi_Sakano@urmc.rochester.edu. ^[2] Department of Biomedical Genetics, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA.;Stem Cell and Regenerative Medicine Institute, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. ^[3] Center for RNA Biology, University of Rochester, Rochester, NY, 14642, USA.;Department of Otolaryngology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. ^[4] Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, Rochester, NY, 14642, USA. Lynne_Maquat@urmc.rochester.edu.;Center for RNA Biology, University of Rochester, Rochester, NY, 14642, USA. Lynne_Maquat@urmc.rochester.edu. ^[5]

关键词 Cerebellum Cortex Fmr1-KO mouse Fragile X protein (FMRP), Upframeshift protein 1 (UPF1)Fragile X syndrome Hippocampus Mouse brain development Nonsense-mediated mRNA decay (NMD)