Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects.

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第一作者： Ilaria,Romito

第一单位： Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, Via S. Paolo, 15, 00146, Rome, Italy.

作者： Ilaria,Romito ^[1] ; Manuela,Porru ^[2] ; Maria Rita,Braghini ^[1] ; Luca,Pompili ^[2] ; Nadia,Panera ^[1] ; Annalisa,Crudele ^[1] ; Daniela,Gnani ^[3] ; Cristiano,De Stefanis ^[4] ; Marco,Scarsella ^[4] ; Silvia,Pomella ^[5] ; Stefano,Levi Mortera ^[6] ; Emmanuel,de Billy ^[5] ; Adrian Libenzio,Conti ^[4] ; Valeria,Marzano ^[6] ; Lorenza,Putignani ^[7] ; Manlio,Vinciguerra ^[8] ; Clara,Balsano ^[9] ; Anna,Pastore ^[10] ; Rossella,Rota ^[5] ; Marco,Tartaglia ^[11] ; Carlo,Leonetti ^[2] ; Anna,Alisi ^[12]

作者单位： Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, Via S. Paolo, 15, 00146, Rome, Italy. ^[1] Unit of Oncogenomic and Epigenetic, IRCCS Regina Elena National Cancer Institute, Rome, Italy. ^[2] Experimental Imaging Center, IRCCS San Raffaele Scientific Institute, 20132, Milan, Italy. ^[3] Core Facilities, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. ^[4] Department of Paediatric Haematology/Oncology and Cellular and Gene Therapy, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. ^[5] Unit of Human Microbiome, Multimodal Laboratory Medicine Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. ^[6] Unit of Human Microbiome, Multimodal Laboratory Medicine Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.;Unit of Microbiomics, Microbiology and Immunological Diagnostics, Department of Diagnostics and Laboratory Medicine Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. ^[7] International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic.;Department of Translational Stem Cell Biology, Research Institute of the Medical University of Varna, 9002, Varna, Bulgaria. ^[8] Department of Life, Health and Environmental Sciences MESVA, University of L'Aquila, L'Aquila, Italy.;Francesco Balsano Foundation, Rome, Italy. ^[9] Research Unit of Diagnostical and Management Innovations, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. ^[10] Genetics and Rare Diseases Research Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. ^[11] Unit of Molecular Genetics of Complex Phenotypes, Bambino Gesù Children's Hospital, IRCCS, Via S. Paolo, 15, 00146, Rome, Italy. anna.alisi@opbg.net. ^[12]

关键词 Epigenetic FAK HCC Sorafenib Therapy