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A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.

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第一作者: Jun Young,Park
第一单位: Gwangju Alzheimer's & Related Dementia cohort research center, Chosun University, Gwangju, Korea.;Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea.;Neurozen Inc., Seoul, Korea.
作者单位: Gwangju Alzheimer's & Related Dementia cohort research center, Chosun University, Gwangju, Korea.;Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea.;Neurozen Inc., Seoul, Korea. [1] Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea. [2] Gwangju Alzheimer's & Related Dementia cohort research center, Chosun University, Gwangju, Korea. [3] Gwangju Alzheimer's & Related Dementia cohort research center, Chosun University, Gwangju, Korea.;Department of Biomedical Science, Chosun University, Gwangju, Korea. [4] Gwangju Alzheimer's & Related Dementia cohort research center, Chosun University, Gwangju, Korea.;Department of Life Science, Chosun University, Gwangju, Korea. [5] Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea. [6] Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea.;Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. [7] Department of medical consilience, Graduate school, Dankook university, Cheonan, Korea. [8] Gwangju Alzheimer's & Related Dementia cohort research center, Chosun University, Gwangju, Korea.;Department of Neurology, Chosun University Hospital, Gwangju, Korea. [9] Department of Biomedical Science, Chosun University, Gwangju, Korea.;Department of Cellular and Molecular Medicine, Chosun University School of Medicine, Gwangju, Korea. [10] Department of Life Science, Chung-Ang University, Seoul, Korea. [11] Department of Medical Science, College of Medicine, Catholic Kwandong University, Gangneung, Korea. [12] Department of Software and Computer Engineering, Ajou University, Suwon-si, Korea. [13] Department of Psychiatry, University of Oxford, Oxford, UK. [14] College of Pharmacy, Chosun University, Gwangju, Korea. [15] Department of Nuclear Medicine, Samsung Medical Center, Seoul, Korea. [16] Department of Neurology, Chonnam National University Medical School, Gwangju, Korea. [17] Department of Neurology, Seoul National University College of Medicine and Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea. [18] Indiana Alzheimer's Disease Research Center and Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA. [19] Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA. [20] Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.;Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA.;Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [21] Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Korea. won1@snu.ac.kr.;Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Korea. won1@snu.ac.kr.;Institute of Health and Environment, Seoul National University, Seoul, Korea. won1@snu.ac.kr.;RexSoft Corps, Seoul, Korea. won1@snu.ac.kr. [22] Gwangju Alzheimer's & Related Dementia cohort research center, Chosun University, Gwangju, Korea. leekho@chosun.ac.kr.;Neurozen Inc., Seoul, Korea. leekho@chosun.ac.kr.;Department of Biomedical Science, Chosun University, Gwangju, Korea. leekho@chosun.ac.kr.;Department of Life Science, Chosun University, Gwangju, Korea. leekho@chosun.ac.kr.;Korea Brain Research Institute, Daegu, Korea. leekho@chosun.ac.kr. [23]
DOI 10.1038/s41398-021-01680-5
PMID 34785643
发布时间 2022-11-15
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