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Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.

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第一作者： Sven,Kratochvil

第一单位： The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.

作者： Sven,Kratochvil ^[1] ; Chen-Hsiang,Shen ^[2] ; Ying-Cing,Lin ^[1] ; Kai,Xu ^[2] ; Usha,Nair ^[1] ; Lais,Da Silva Pereira ^[2] ; Prabhanshu,Tripathi ^[2] ; Johan,Arnold ^[1] ; Gwo-Yu,Chuang ^[2] ; Eleonora,Melzi ^[1] ; Arne,Schön ^[3] ; Baoshan,Zhang ^[2] ; Marlon,Dillon ^[2] ; Brian,Bonilla ^[2] ; Barbara J,Flynn ^[2] ; Kathrin H,Kirsch ^[1] ; Neville K,Kisalu ^[2] ; Patience K,Kiyuka ^[2] ; Tracy,Liu ^[2] ; Li,Ou ^[2] ; Marie,Pancera ^[4] ; Reda,Rawi ^[2] ; Mateo,Reveiz ^[2] ; Kareen,Seignon ^[1] ; Lawrence T,Wang ^[2] ; Michael T,Waring ^[5] ; John,Warner ^[1] ; Yongping,Yang ^[2] ; Joseph R,Francica ^[2] ; Azza H,Idris ^[6] ; Robert A,Seder ^[7] ; Peter D,Kwong ^[8] ; Facundo D,Batista ^[9]

作者单位： The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. ^[1] Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA. ^[2] Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA. ^[3] Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA; Vaccine Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ^[4] The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. ^[5] The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA; Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA. ^[6] Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: rseder@nih.gov. ^[7] Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: pdkwong@nih.gov. ^[8] The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA. Electronic address: fbatista1@mgh.harvard.edu. ^[9]

关键词 PfCSP adoptively transferred B cells antibody CIS43 circumsporozoite epitope-focused immunization in situ vaccination junctional epitope malaria passive protective