Microbial transformation of pentacyclic triterpenes for anti-inflammatory agents on the HMGB1 stimulated RAW 264.7 cells by Streptomyces olivaceus CICC 23628.

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第一作者： Yuyuan,Zhu

第一单位： State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China.

作者： Yuyuan,Zhu ^[1] ; Pingping,Shen ^[1] ; Jiayi,Wang ^[1] ; Xuewa,Jiang ^[1] ; Wei,Wang ^[1] ; Richa,Raj ^[1] ; Haixia,Ge ^[2] ; Weiwei,Wang ^[3] ; Boyang,Yu ^[4] ; Jian,Zhang ^[5]

作者单位： State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China. ^[1] School of Life Sciences, Huzhou University, Huzhou 313000, PR China. ^[2] State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China. ^[3] Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China. ^[4] State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China Pharmaceutical University, Nanjing 211198, PR China; ZhenPing Expert Workstation for Zhang Jian, Zhenping, Ankang, Shaanxi 725699, PR China. Electronic address: wilsonzhang99@cpu.edu.cn. ^[5]

关键词 3,4-seco-triterpenes Anti-inflammatory activity Biotransformation High mobility group box-1 protein Pentacyclic triterpenes Streptomyces olivaceus CICC 23628