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首页> Free radical biology & medicine> Nitric oxide protects against cochlear hair cell damage and noise-induced hearing loss through glucose metabolic reprogramming.

Nitric oxide protects against cochlear hair cell damage and noise-induced hearing loss through glucose metabolic reprogramming.

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作者： Haidi,Yang ^[1] ; Yafeng,Zhu ^[2] ; Yongyi,Ye ^[3] ; Jiao,Guan ^[2] ; Xin,Min ^[1] ; Hao,Xiong ^[4]

作者单位： Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China. ^[1] Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. ^[2] Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. ^[3] Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Institute of Hearing and Speech-Language Science, Sun Yat-sen University, Guangzhou, China. Electronic address: xiongh7@mail.sysu.edu.cn. ^[4]

关键词 Cochlea Hearing loss Nitric oxide Oxidative stress Pyruvate kinase M2 S-Nitrosylation

主题词动物(Animals);耳蜗(Cochlea);葡萄糖(Glucose);毛细胞, 听觉, 外(Hair Cells, Auditory, Outer);听觉丧失, 噪声性(Hearing Loss, Noise-Induced);过氧化氢(Hydrogen Peroxide);小鼠(Mice);小鼠, 近交CBA(Mice, Inbred CBA);一氧化氮(Nitric Oxide)

DOI 10.1016/j.freeradbiomed.2021.11.020

PMID 34801666

发布时间 2022-01-31

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Free radical biology & medicine

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