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Machine learning-based method for tacrolimus dose predictions in Chinese kidney transplant perioperative patients.

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第一作者： Qun,Fu

第一单位： School of Pharmacy, Nanchang University, Nanchang, China.;Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.

作者： Qun,Fu ^[1] ; Yan,Jing ^[1] ; Guozhen,Liu Mr ^[2] ; Xuehui,Jiang Mr ^[1] ; Hong,Liu ^[3] ; Ying,Kong ^[3] ; Xiongjun,Hou ^[4] ; Lei,Cao ^[5] ; Pei,Deng ^[5] ; Pin,Xiao ^[6] ; Jiansheng,Xiao ^[7] ; Hongwei,Peng ^[3] ; Xiaohua,Wei ^[8]

作者单位： School of Pharmacy, Nanchang University, Nanchang, China.;Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China. ^[1] PKU Healthcare IT Co, Ltd, Beijing, China. ^[2] Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China. ^[3] Department of Clinical Pharmacology, Jiangxi Provincial People's Hospital, Nanchang, China. ^[4] Department of Information, The First Affiliated Hospital of Nanchang University, Nanchang, China. ^[5] Department of Pharmacy, Hospital of Jiangxi Provincial Armed Police Corps, Nanchang, China. ^[6] Department of Transplantation, The First Affiliated Hospital of Nanchang University, Nanchang, China. ^[7] Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.;Institute of Clinical Pharmacology, Jiangxi Institute of Clinical Medical Sciences, Nanchang, China. ^[8]

关键词 CYP3A4 CYP3A5 dose prediction model extra trees regressor kidney transplant machine learning tacrolimus

医学主题词中国(China);细胞色素P-450 CYP3A(Cytochrome P-450 CYP3A);基因型(Genotype);人类(Humans);免疫抑制剂(Immunosuppressive Agents);肾移植(Kidney Transplantation);他罗利姆(Tacrolimus)

DOI 10.1111/jcpt.13579

PMID 34802160

发布时间 2022-05-23

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