<i>In vitro-in vivo</i> availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model.

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作者： Aline de Sousa Barbosa Freitas,Pereira ^[1] ; Maria Laura,de Souza Lima ^[1] ; Arnobio Antonio,da Silva-Junior ^[2] ; Emanuell,Dos Santos Silva ^[2] ; Raimundo Fernandes,de Araújo Júnior ^[3] ; Agnes Andrade,Martins ^[4] ; Jovelina Samara Ferreira,Alves ^[5] ; Artur de Santana,Oliveira ^[5] ; Leandro,De Santis Ferreira ^[5] ; Emily Cintia Tossi,de Araújo Costa ^[6] ; Gerlane Coelho Bernardo,Guerra ^[7] ; Caroline Addison Carvalho Xavier,de Medeiros ^[8] ; Gerly A C,Brito ^[9] ; Renata Ferreira,de Carvalho Leitao ^[10] ; Aurigena Antunes,de Araújo ^[11]

作者单位： Post-Graduation Program in Oral Science, Department of Dentistry, UFRN, Natal, Brazil. ^[1] Postgraduate Program in Pharmaceutical Science, Federal University of Rio Grande do Norte, Natal, Brazil. ^[2] Post-Graduation program in Functional and Structural Biology/Post-graduation program Health Science/Department of Morphology, UFRN, Natal, Brazil. ^[3] Department of Dentistry, UFRN, Natal, Brazil. ^[4] Drug Quality Control Laboratory (LCQMed), Department of Pharmacy, UFRN, Natal, Brazil. ^[5] Institute of Chemistry, UFRN, Natal, Brazil. ^[6] Post-Graduation Program in Biochemistry and Molecular Biology/Post-Graduation Program in Pharmaceutical Science, Department of Biophysics and Pharmacology, UFRN, Natal, Brazil. ^[7] Post-Graduation Program in Biochemistry and Molecular Biology/Post-Graduation Program in RENORBIO, Department of Biophysics and Pharmacology, UFRN, Natal, Brazil. ^[8] Postgraduate Program in Pharmacology, Postgraduate Program in Morphology, Department of Morphology, UFC, Fortaleza, Brazil. ^[9] Postgraduate Program in Morphology, Department of Morphology, UFC, Fortaleza, Brazil. ^[10] Post-Graduation Program Oral Science/Post-Graduation Program in Pharmaceutical Science, Department of Biophysics and Pharmacology, UFRN, Natal, Brazil. ^[11]

关键词 Polylactic-co-glycolic acid bioavailability diabetes