Validation of a simple liquid chromatography coupled to tandem mass spectrometry method for the simultaneous determination of tacrolimus, sirolimus, everolimus and cyclosporin A in dried matrix on paper discs.
第一单位:
Laboratory of Mass Spectrometry, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
作者:
关键词
C0, Pre-dose trough concentrationC2, 2-hour post-dose concentrationCS, Calibration standardCV, Coefficient of variationDBS, Dried blood spotsDMPS, Dried matrix on paper discsDried matrix on paper discs (DMPD)ESI+, Positive electrospray source ionization modeHematocritHt, HematocritICb95, 95 confidence interval for interceptsICm95, 95 confidence interval for slopesImmunosuppressantsLC-MS/MS, Liquid chromatography coupled to tandem mass spectrometryLLOQ, Lower limit of quantitationLSS, Limited sampling strategyLiquid chromatography coupled to tandem mass spectrometry (LC-MS/MS)Method comparisonPCDBS, Pre-cut dried blood spotsPDBS, Perforated dried blood spotsPIs, Prediction intervalsQC, Quality control samplesR, Relative recoveryRE, Percentage of the relative errorZnSO4·7H2O, Zinc sulfate heptahydrate[M+NH4]+, Ammoniated adductmTOR, Mechanistic target of Rapamycin
DOI
10.1016/j.jmsacl.2021.01.003
PMID
34820661
发布时间
2024-04-04
- 浏览2
Journal of mass spectrometry and advances in the clinical lab
2021年19卷
7-19页
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