第一单位：
Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
作者：
Alastair J H,Brown [1]
;
Sophie J,Bradley [2]
;
Fiona H,Marshall [1]
;
Giles A,Brown [1]
;
Kirstie A,Bennett [1]
;
Jason,Brown [1]
;
Julie E,Cansfield [1]
;
David M,Cross [3]
;
Chris,de Graaf [1]
;
Brian D,Hudson [1]
;
Louis,Dwomoh [4]
;
João M,Dias [1]
;
James C,Errey [1]
;
Edward,Hurrell [1]
;
Jan,Liptrot [1]
;
Giulio,Mattedi [1]
;
Colin,Molloy [4]
;
Pradeep J,Nathan [5]
;
Krzysztof,Okrasa [1]
;
Greg,Osborne [1]
;
Jayesh C,Patel [1]
;
Mark,Pickworth [1]
;
Nathan,Robertson [1]
;
Shahram,Shahabi [6]
;
Christoffer,Bundgaard [7]
;
Keith,Phillips [6]
;
Lisa M,Broad [6]
;
Anushka V,Goonawardena [8]
;
Stephen R,Morairty [8]
;
Michael,Browning [9]
;
Francesca,Perini [10]
;
Gerard R,Dawson [11]
;
John F W,Deakin [12]
;
Robert T,Smith [1]
;
Patrick M,Sexton [13]
;
Julie,Warneck [14]
;
Mary,Vinson [1]
;
Tim,Tasker [1]
;
Benjamin G,Tehan [1]
;
Barry,Teobald [1]
;
Arthur,Christopoulos [15]
;
Christopher J,Langmead [16]
;
Ali,Jazayeri [1]
;
Robert M,Cooke [1]
;
Prakash,Rucktooa [1]
;
Miles S,Congreve [1]
;
Malcolm,Weir [17]
;
Andrew B,Tobin [18]
作者单位：
Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK.
[1]
Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
[2]
Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Cross Pharma Consulting Ltd, 20-22 Wenlock Road, London, N17GU, UK.
[3]
The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
[4]
Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Herchel Smith Building, Cambridge, CB20SZ, UK.
[5]
Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK.
[6]
Eli Lilly & Co, Neuroscience Discovery, Erl Wood Manor, Windlesham, Surrey, GU20 6PH, UK; H. Lundbeck A/S, Neuroscience Research, Ottiliavej 9, 2500 Valby, Copenhagen, Denmark.
[7]
Center for Neuroscience, Biosciences Division, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
[8]
University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX12JD, UK; P1vital, Manor house, Howbery Buisness Park, Wallingford, OX108BA, UK.
[9]
Centre for Cognitive Neuroscience - Duke-NUS Medical School, 8 College Road, 169857, Singapore.
[10]
University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX12JD, UK.
[11]
Neuroscience and Psychiatry Unit, University of Manchester, Manchester, M139PT UK.
[12]
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia.
[13]
Protogenia Consulting Ltd, PO-Box 289, Ely, CB79DR, UK.
[14]
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia.
[15]
Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences and Department of Pharmacology, Monash University, Parkville 3052, Victoria, Australia.
[16]
Sosei-Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK. Electronic address: malcolm.weir@soseiheptares.com.
[17]
The Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK. Electronic address: andrew.tobin@glasgow.ac.uk.
[18]
主题词
老年人(Aged);老年人, 80以上(Aged, 80 and over);衰老(Aging);阿尔茨海默病(Alzheimer Disease);氨基酸序列(Amino Acid Sequence);动物(Animals);血压(Blood Pressure);CHO细胞(CHO Cells);胆碱酯酶抑制剂(Cholinesterase Inhibitors);仓鼠属(Cricetulus);结晶(Crystallization);疾病模型, 动物(Disease Models, Animal);狗(Dogs);药物设计(Drug Design);脑电描记术(Electroencephalography);女(雌)性(Female);HEK293细胞(HEK293 Cells);心率(Heart Rate);人类(Humans);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);模型, 分子(Models, Molecular);分子动力学模拟(Molecular Dynamics Simulation);神经变性(Nerve Degeneration);灵长目(Primates);大鼠(Rats);受体, 毒蕈碱M1(Receptor, Muscarinic M1);信号传导(Signal Transduction);结构同源性, 蛋白质(Structural Homology, Protein);小鼠(Mice)
DOI
10.1016/j.cell.2021.11.001
PMID
34822784
发布时间
2024-07-14
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