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On the Validity of the Stochastic Quasi-Steady-State Approximation in Open Enzyme Catalyzed Reactions: Timescale Separation or Singular Perturbation?

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第一作者： Justin,Eilertsen

第一单位： Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.;Mathematical Reviews, American Mathematical Society, 416 4th Street, Ann Arbor, MI, 48103, USA.

作者： Justin,Eilertsen ^[1] ; Santiago,Schnell ^[2]

作者单位： Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.;Mathematical Reviews, American Mathematical Society, 416 4th Street, Ann Arbor, MI, 48103, USA. ^[1] Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. santiago.schnell@nd.edu.;Department of Computational Medicine & Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, 48109, USA. santiago.schnell@nd.edu.;Department of Biological Sciences, and Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, IN, 46556, USA. santiago.schnell@nd.edu. ^[2]

关键词 Fenichel theory Langevin equation Linear noise approximation Michaelis–Menten reaction mechanism Quasi-steady-state approximation Singular perturbation Slow scale linear noise approximation Stochastic process Tikhonov’s theorem

医学主题词催化作用(Catalysis);酶类(Enzymes);动力学(Kinetics);数学概念(Mathematical Concepts);模型, 生物学(Models, Biological);随机过程(Stochastic Processes)

DOI 10.1007/s11538-021-00966-5

PMID 34825985

发布时间 2024-04-05

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准确一般字义偏差语意偏离译文作用小提交