Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine.-论文-万方医学网

第一作者： Annick,Jeannerat

第一单位： Applied Research Department, LAM Biotechnologies SA, CH-1066 Épalinges, Switzerland.

作者： Annick,Jeannerat ^[1] ; Cédric,Peneveyre ^[1] ; Florence,Armand ^[2] ; Diego,Chiappe ^[2] ; Romain,Hamelin ^[2] ; Corinne,Scaletta ^[3] ; Nathalie,Hirt-Burri ^[3] ; Anthony,de Buys Roessingh ^[4] ; Wassim,Raffoul ^[5] ; Lee Ann,Applegate ^[5] ; Alexis,Laurent ^[6]

作者单位： Applied Research Department, LAM Biotechnologies SA, CH-1066 Épalinges, Switzerland. ^[1] Proteomics Core Facility and Technology Platform, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. ^[2] Regenerative Therapy Unit, Lausanne University Hospital, University of Lausanne, CH-1066 Épalinges, Switzerland. ^[3] Children and Adolescent Surgery Service, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland. ^[4] Lausanne Burn Center, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland. ^[5] Plastic, Reconstructive, and Hand Surgery Service, Lausanne University Hospital, University of Lausanne, CH-1011 Lausanne, Switzerland. ^[6] Center for Applied Biotechnology and Molecular Medicine, University of Zurich, CH-8057 Zurich, Switzerland. ^[7] Oxford OSCAR Suzhou Center, Oxford University, Suzhou 215123, China. ^[8] Manufacturing Department, TEC-PHARMA SA, CH-1038 Bercher, Switzerland. ^[9]

主题词成脂分化(Adipogenesis);细胞低氧(Cell Hypoxia);细胞增殖(Cell Proliferation);细胞形状(Cell Shape);细胞大小(Cell Size);细胞, 培养的(Cells, Cultured);减量调节(Down-Regulation);细胞外基质蛋白质类(Extracellular Matrix Proteins);胎儿(Fetus);人类(Humans);缺氧诱导因子1, α亚基(Hypoxia-Inducible Factor 1, alpha Subunit);模型, 生物学(Models, Biological);骨生成(Osteogenesis);药用制剂(Pharmaceutical Preparations);表型(Phenotype);参考标准(Reference Standards);再生医学(Regenerative Medicine);腱(Tendons);时间因素(Time Factors);增量调节(Up-Regulation)

DOI 10.3390/cells10112872

PMID 34831095

发布时间 2021-12-23

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Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine.

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Hypoxic Incubation Conditions for Optimized Manufacture of Tenocyte-Based Active Pharmaceutical Ingredients of Homologous Standardized Transplant Products in Tendon Regenerative Medicine.

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