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Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes.

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第一作者： Brian,Onken

第一单位： Nelson Biological Laboratories, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA.

作者： Brian,Onken ^[1] ; Christine A,Sedore ^[2] ; Anna L,Coleman-Hulbert ^[2] ; David,Hall ^[3] ; Erik,Johnson ^[2] ; Eleanor Grace,Jones ^[2] ; Stephen A,Banse ^[2] ; Phu,Huynh ^[1] ; Suzhen,Guo ^[1] ; Jian,Xue ^[1] ; Esteban,Chen ^[1] ; Girish,Harinath ^[1] ; Anna C,Foulger ^[3] ; Elizabeth A,Chao ^[3] ; June,Hope ^[3] ; Dipa,Bhaumik ^[3] ; Todd,Plummer ^[3] ; Delaney,Inman ^[3] ; Mackenzie,Morshead ^[3] ; Max,Guo ^[4] ; Gordon J,Lithgow ^[3] ; Patrick C,Phillips ^[2] ; Monica,Driscoll ^[1]

作者单位： Nelson Biological Laboratories, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, USA. ^[1] Institute of Ecology and Evolution, University of Oregon, Eugene, Oregon, USA. ^[2] The Buck Institute for Research on Aging, Novato, California, USA. ^[3] Division of Aging Biology, National Institute on Aging, Bethesda, Maryland, USA. ^[4]

关键词 anti-diabetes drug biguanide genetic diversity healthspan longevity

医学主题词衰老(Aging);动物(Animals);秀丽新小杆线虫(Caenorhabditis elegans);人类(Humans);降血糖药(Hypoglycemic Agents);长寿(Longevity);二甲双胍(Metformin);治疗结果(Treatment Outcome)

DOI 10.1111/acel.13488

PMID 34837316

发布时间 2022-12-02

基金项目

U01 AG045829/AG/NIA NIH HHS/United States U01 AG045844/AG/NIA NIH HHS/United States U01 AG045864/AG/NIA NIH HHS/United States U24 AG056052/AG/NIA NIH HHS/United States

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