Genome annotation with long RNA reads reveals new patterns of gene expression and improves single-cell analyses in an ant brain.

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作者： Emily J,Shields ^[1] ; Masato,Sorida ^[2] ; Lihong,Sheng ^[1] ; Bogdan,Sieriebriennikov ^[1] ; Long,Ding ^[3] ; Roberto,Bonasio ^[4]

作者单位： Epigenetics Institute and Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. ^[1] Department of Urology and Institute of Neuropathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. ^[2] Department of Biology, New York University, New York, NY, USA. ^[3] Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA. ^[4] Epigenetics Institute and Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. roberto@bonasiolab.org. ^[5]

关键词 3′ UTR annotation Alternative splicing Ants Genome annotation Harpegnathos saltator Iso-Seq Long-read RNA-seq Single-cell sequencing

主题词 3'非翻译区(3' Untranslated Regions);动物(Animals);蚁(Ants);脑(Brain);分子序列注释(Molecular Sequence Annotation);序列分析, RNA(Sequence Analysis, RNA);单细胞分析(Single-Cell Analysis)

DOI 10.1186/s12915-021-01188-w

PMID 34838024

发布时间 2024-04-04

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