Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation.
第一作者:
Diana M,Acosta
第一单位:
Department of Biochemistry and Program in Structural Biology, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, New York, USA.
作者:
医学主题词
阿尔茨海默病(Alzheimer Disease);人类(Humans);赖氨酸(Lysine);微管(Microtubules);神经原纤维缠结(Neurofibrillary Tangles);磷酰化(Phosphorylation);蛋白质加工, 转译后(Protein Processing, Post-Translational);微管蛋白(Tubulin);tau蛋白质类(tau Proteins)
DOI
10.1016/j.jbc.2021.101442
PMID
34838590
发布时间
2022-05-31
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